|
KMID : 0613820170270101225
|
|
Journal of Life Science
2017 Volume.27 No. 10 p.1225 ~ p.1231
|
|
|
Circadian Clock Genes, PER1 and PER2, as Tumor Suppressors
|
|
Son Beom-Seok
Do Hyun-Hee
Kim Eun-Gi
Youn Bu-Hyun
Kim Wan-Yeon
|
|
|
Abstract
|
|
|
|
Disruptive expression patterns of the circadian clock genes are highly associated with many human diseases, including cancer. Cell cycle and proliferation is linked to a circadian rhythm; therefore, abnormal clock gene expression could result in tumorigenesis and malignant development. The molecular network of the circadian clock is based on transcriptional and translational feedback loops orchestrated by a variety of clock activators and clock repressors. The expression of 10~15% of the genome is controlled by the overall balance of circadian oscillation. Among the many clock genes, Period 1 (Per1) and Period 2 (Per2) are clock repressor genes that play an important role in the regulation of normal physiological rhythms. It has been reported that PER1 and PER2 are involved in the expression of cell cycle regulators including cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors. In addition, correlation of the down-regulation of PER1 and PER2 with development of many cancer types has been revealed. In this review, we focused on the molecular function of PER1 and PER2 in the circadian clock network and the transcriptional and translational targets of PER1 and PER2 involved in cell cycle and tumorigenesis. Moreover, we provide information suggesting that PER1 and PER2 could be promising therapeutic targets for cancer therapies and serve as potential prognostic markers for certain types of human cancers.
|
|
|
KEYWORD
|
|
|
Circadian rhythm, clock gene, cell cycle, PER1, PER2, tumor suppressor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|